3 failed IUI's The major difference is that, by cutting the dose of Lupron down to one sixth of the routine dose, and by giving it twice daily, the Lupron actually turns the pituitary gland on rather than off, producing major release of FSH. Femara-Antagonist Protocol. I just pray it works. Right now, they are doing an antagonistic approach. -We're both. It is used for patients who are "low responders." Low responders are patients who have had a previous cycle that yielded 4 oocytes or less. 9dp5dt Beta 1 = 344!! I wonder what if that's the cycle that had the normal egg. I'm 36 & TTC 2 yrs. No frosties. 150 iu follistim and 75 iu menopure didn't work either. Got 9 eggs, 4 were mature, 3 fertilized, 2 didn't make it and the 1 that made it to blast tested abnormal. Sounds like CC.RM is doing EPP Oprah-style. My RE wants to use a lupron microdose protocol. Then di, I had a regular IVF cycle 1 month ago. Then it'll be a flare approach, but Dr C said I would still be on a high dose with meds. We started our IVF journey in 2014. You can continue to take oestrogen throughout if you want. With IVF#2, I got 16 eggs, 15 of which were mature. Texas Fertility Center has brought world-class care to San Antonio, Austin, Round Rock, Central Texas, and the entire Southwestern United States. This seems really high for someone that is not a poor responded, no? I wanted to know for those who have PCOS (i have mild PCOS) which IVF protocol yielded a BFP for you ? This is a community for those who have gotten pregnant after a struggle with infertility. ODWU revealed blocked tube(s). ?Put back 2 day 5 embryos and now I am here. Stimulation Day 1 You will start gonadotropin injections today. ", Feb'12- July'12-testing(all clear minus slight arcuate ute), 3 IUI with clomid all BFN, ET 9/14 2 embies transferred. In order to retrieve the eggs before they ovulate spontaneously, the patient is taken into the operating room and the eggs are removed non-surgically approximately 36 hours following hCG administration. [Sheri] What is DHEA? Besides, I hear regular lupron sucks so I'm grateful I didn't have to do that part. My doctor said he will keep adjusting me based on my scan results. This is my second attempt at ivf my first ivf was unsuccessful no embryos made it to day 5. As the poor responder is one of the more challenging issues facing the reproductive endocrinologist today, and as there are no magic bullet regimens to stimulate these patients effectively, many alternative protocols to the flare have been proposed. Thanks everyone. But ER 1 and 2 antagonist, next antagonist +HGH = 0 blasts ER 3 MDLF = 2 untested day 6, 5 AA.. but ER3 was 6 months after ER1 so not sure if it was supplements/lifestyle changes which did the trick. You had a cyvle with 11 eggs. 43 doing mini-IVF, does this protocol look good? Good luck for your scan tomorrow! The lupron over suppresses my ovaries and they don't respond well even to high doses of Bravelle or Follistim or Gonal-f, so I am trying the antagonist protocol next with ganirelix. Is this normal??? When I picked up my meds today, and the guy told me which to refrigerate, he then quickly said "oh ya, you already know that. I took BCP for 3 weeks. I have a normal AMH for my age but I've read this protocol is for DOR or poor responders. Short Lupron (Microdose or Flare) Protocol for IVF. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Beta 2 = 4822 7wk u/s= 2 heartbeats! I did lupron stop protocol for IVF#1, but I was still oversuppressed. I feel like it's always better to go slow & steady. My E2 never soared like some women'son the day of my trigger my E2 was only 1563, but I still got 16 eggs. 0000006212 00000 n If so, I'd love to hear thoughts/experiences. I'm praying this protocol will be successfull for us. It can prolong the survival of sperm by depositing them directly into the uterus and avoiding the hostile environment of the vagina. I am sure of it! This handout is staff as legal aid cannot provide patients with general information. Our beautiful little girl arrived January 2015! MD said after that many years that the chance of a successful reversal is slim and none and that our best chance would be IVF. And Yay for no BCP, I hate that stuff, I've done all the different methods with the exception of EPP. HiI'm new. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. An estrogen primed microdose lupron cycle is the only cycle that works for my body - we've tried non-primed, clomid antagonist, and standard antagonist, struggling with maturity, fertilization and egg to blast ratio. Vicodin(20 tabs),plus a refill x2(Did not refill/use) So, we concluded that the microdose flare-up protocol may have a better outcome in poor-responder patients. Beta1 9/10: 152.7! 1Frostie. I had wanted to try the EPP if my #4 didn't work/give me frosties..because I've seen so much success with it. After another failed IVF attempt using the Microdose Lupron protocol, my RE now suggests the Estrogen Patch protocol as I am a poor responder. 3F. 9 eggs retrieved, 2 fertilized with ICSI, 1 arrest on day 3, the other arrested on day 5. Dr. C apologized for the fucking nightmare of a cancelled cycle, and implied that maybe the other doctor we were seeing in the practice should have put the breaks on way before day 10 because there was LITERALLY NO RESPONSE. i actually have a little extra orlissa, in case you'd like me to send it to you? Yeah I was a poor responder my last cycle and i was on a lot of lupron. Good luck! I am just terrified it will be like my last cycle. I did get 4 chromosomally normal embryos from 3 cycles (we did PGS on day 6 blasts). DH and I have been TTC for 4.5 years or so: Our IVF #1 was cancelled in March due to low response to stims. EPP gave meFIVE- three CCS normal! Find other members in this community to connect with. Dont get discouraged. I have low thyroid, endometriosis, blocked tubes & diminished ovarian reserve. I went through Dr. Geoffrey sher from SIRM, who mentioned that a high LH surge initially with lupron flare or clomid or menopur can cause low quality. So Im not sure how that changes for you, since you were able to get eggs. I tried IVF in may since my follicle count was low I cancelled it. We also added microfluidics to our last two cycles, you can check out the Zymot chip and ended up with twice the number of embryos that made it to blast. I'm starting IVF#3 on November 14th. Microdose lupron protocol This is a very popular protocol for low responders with diminished ovarian reserve. sometimes a bcp is used for this same purpose. Estrogen Primed Antagonist Protocol. The average number of days of taking the FSH injections is 8-10, with the range being . Countless BFN(s) Valium(1 tab) Since TFC opened its doors more than 40 years ago, we have helped our patients deliver 23,000 miracles through IVF, IUI, egg donation, intracytoplasmic sperm injection, and reconstructive fertility surgery. I'm 43 and DOR. Have the embryos tested for sure and if itdoesnt work out I will give you all the info for embryo adoption. The use of MCDL can improve the patient's response to gonadotropin therapy. And can someone generally explain the 'steps' to me? Thoughts on different protocols? This is is my best response so far as I've never before had blasts to freeze. [curious1] lcurtis8, it's a hormone that we produce plentiful as younger adults; as we age it decreases. My personal opinion is that even though I have read over and over again that it is a DOR / poor responder protocol, the people I seem to see having success with it are not really in that category. Amazing! Going with a microdose lupron protocol for my 2nd, starting on 11/30. Background: I'm 35. Er 5: oct 2020 - same protocol as er 4- 4 mature eggs, no blasts Er 6- jan 2021- GH and estrace priming for 4 days. Please specify a reason for deleting this reply from the community. What's weird is all of my levels are normal and i'm so young so i think the doctor and nurses are all perplexed as to how my egg quality was so bad! Then 2X10U Lupron and 2X225U Gonal-F per day for 10 days. trouble breathing. Four mature eggs were retrieved. The use of Lupron has effectively eliminated the risk of OHSS . He has two girls from a previous marriage. They are in a.different country and I cant travel due to covid restrictions. I will be doing it again for hopefully baby 2 in a couple of months but with higher stim dosage to get more mature and taking CoQ10 and DHEA for more fertilized. Hello! It's a Girl, EDD April 7, 2014. I did microdose lupron flare protocol with my first IVF. They have me on Follistim, Low Dose HCG, and Ganirellex. Instead, we've had two "highly unusual" experiences and I could really use some input. Anyway, I am doing the EPP this round and was curious to hear some of your experiences with it. From what I have read, it is common in women with DOR and poor responders. It was fucking ridiculous to us, because not only were we injecting about $800 worth of meds (450 IUI Follistim and 10 iu low dose HCG) into my body for 10 days, but it took them 10 days to realize I was a no responder. From what I've read on the boards, the start of FET prep typically begins 30 days after Injection #2. With IVF#2, we did MDL. At 39, you still have a good chance. After two failed IUI cycles, my RE decided to start me on an EPP to prep for next cycle. I really believe that its a miracle protocol for those who are poor responders. Lupron Depot is used in women to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids. Objective: To compare the effect of the GnRH antagonist/letrozole protocol (AL) with the microdose GnRH agonist flare-up (MF) protocol in poor ovarian responders for intracytoplasmic sperm injection (ICSI). Medr, I'm new to this site, but I would love to hear from others who have the shared diagnosis of unexplained infertility. (ex. Was wonderin, Hi ladies - Don't be offended with this NOOB question! Unfortunately, one of them did not thaw successfully. Doc said it was odd and confusing why that last cycle was such a winner so again, may have been just lucky. I had my first cycle canceled due to poor response to stims and ovulating through the lup.. My next cycle will be with EPP no BCP, but keeping the same Lup. startxref However, that information will still be included in details such as numbers of replies. The reason they had me on that protocol was because a) I generally respond GREAT to drugs, and b) my AFC is pretty fine and my age is "young-ish" so they think my low AMH will just mean to expect slightly fewer eggs that will be good quality. For those of you unfamiliar, mini stim is for poor responders who don't have much luck in obtaining a large number of eggs. However, that information will still be included in details such as numbers of replies. I definitely dont feel like myself but not as bloated yet. 0000003240 00000 n When I stimmed, this is also the thickest I ever was. Only thing I can pinpoint is age. Others involve newer supplements such as DHEA, and still others involve the use of injectable medications such as growth hormone. Aug. '13 Attempt at IVF #1 with Lurpon Flare- Canceled due to ovulation through Lupron. November IVF Protocol - DOR / LOW AMH / +40. But I'll let you know if I respond better! Following. Experience with Estrogen Priming Protocol? Only got 1 mature egg and embryothat didnt make it. Reddit and its partners use cookies and similar technologies to provide you with a better experience. I'm sorry to hear about your 2 unsuccessful transfers. I see! Group Black's collective includes Essence, The Shade Room and Naturally Curly. However other had mature egg and we did Icsi by it didn't grow from there. I performed poorly with estrogen priming, so we are taking it out now.hsve you started stim? Now.our concern is premature ovulation and he is monitoring me more for that. does your doctor use a medication called "orlissa" ? I have only ever done 150 and 225 and responded very well. Now I wait for day 5 and then onto to PGTA testing. Lap 2/15. Any advice is welcome! GnRH agonists like Lupron are primarily used for the treatment of endometriosis and fibroids. Since then its been a nightmare to thicken my lining. This is the protocol Im planning to try next (after a cancelled antagonist protocol that only yielded 2 follicles). During a short protocol, Lupron is first introduced during the stimulation phase. xref I'm about to start a microdose lupron flare cycle tomorrow! One ended up with one pgs normal (but my numbers were cut down by needing to pgd as well so we had to discard at least one euploid in this cycle) Next try I got 13 eggs, I think 8 fertilized, we sent 5 good/excellent blasts off and got 2 more pgs/pgd normals. Im currently doing vaginal Estrace (twice a day), vaginal viagra (four times a day), 3 estrogen patches all the time, vitamin e, baby aspirin, and I even started estrogen injections twice a wee, I'm having lining issues and wondering I'd anyone else out there has as well and what your solution/protocol was to thicken the lining. Now going to try a mini IVF at a different clinic because we need to upgrade egg quality. IVF3 (ICSI/CCS): Antagonist with EPP Our most common protocol utilizes Lupron as a trigger instead of hCG to mature follicles prior to egg collection. We have our last PGD embie and my transfer has already been been cancelled 3 times! While some practices make a big deal over the choice of gonadotropin (some use only recombinant FSH, such as Gonal F or Follistim while others primarily use urinary hMG drugs such as Bravelle or Menopur), most studies suggest that there is very little if any difference in pregnancy rates between the different medications. Hence we see mini-IVF protocols used at places like New Hope Fertility in NYC (http://www.newhopefertility.com/?topic=minimal-stimulation-mini-ivf) and the Infertility Center of St Louis (http://www.infertile.com/closlook/biograph.htm); and, 5/15 Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. EPP with CCRM has been my best cycle yet in regards to embryo quantity and quality! Does anyone have any advise or success stories about this protocol. Long Lupron protocol. Baby girl born Aug 2013 What I have seen in my years of fertility groups for women with DOR is that it seems many of our bodies like femara. With my day 6 u/s, the lupron was reduced to 5 units in the morning a, Hey, if you've done the EPP protocol, can you tell me more about it? How long did you wait for next cycle? Pressing Forward 9 eggs retrieved, 2 fertilized with ICSI, 1 arrest on day 3, the other arrested on day 5. No MFI at all. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. Estrogen Priming Microdose Lupron (MDL) *If you receive your period, (cycle day one, the first day of a full flow red) after 5pm, call to speak to a nurse . But other doctors have mentioned that it is great for women with DOR. Thanks! With IVF#1, I only got 2-3 mature follies. My little one is a success story from MDL! Round Three Result 6/25: BFN 0000000960 00000 n I'm going to talk to the doctor soon about our options. I did 10 days of BCP, then Lupron, repronex and Gonal-F for about 10 days. Jo, have you heard of the estrogen priming protocol? Estrogen Primed Antagonist Protocol. Hello all, I need some feedback. Only recently. BFP on FRER 5dp5dt: IN SHOCK! Well, if any of you can share tips, advice, experiencesI would greatly appreciate it! Sept. '13 - We will try again with EPP. I think it helps with the 2ww. Significantly fewer eggs than follicles? Has anybody here had an experience with this protocol and was it successful? estrogen priming is just another way to avoid cysts and quiet your ovaries before starting stim. My FSH is 12. I had 4 but 3 stopped growing around day 6 so they weren't frozen. I also estrogen primed for this one - so it was a slow and steady stimming process, but I am not unhappy about the yield. For how long was the MDL given ? Team Purple. BFN, 7/13 IVF#3 Long lupron protocol with PIO, Crinone, Prometrium, and vivelle, (plus synthroid, metformin, baby asa, metanx, PNV, Vit E, D, calcium, fish oil, CoQ10, IVIg infusions and lovenox per Dr. Kwak-kim). To avoid cysts and quiet your ovaries before starting stim, 2 fertilized with ICSI, arrest! Success story from MDL estrogen priming protocol protocol Im planning to try mini... Doc said it was odd and confusing why that last cycle but I 'll let you know if I better! A lot of lupron / low AMH / +40 jo, have you heard of the estrogen protocol. Different methods with the range being high dose with meds & steady if itdoesnt work out I give! Now.Our concern is premature ovulation and he is monitoring me more for that uterine. With ICSI, 1 arrest on day 3, the start of FET prep typically begins 30 after. Next ( after a cancelled antagonist protocol that only yielded 2 follicles ) 'll be a approach. Ever was out now.hsve you started stim cycles, my RE wants to use a medication called orlissa. Now.Hsve you started stim this protocol and was curious to hear thoughts/experiences 13 attempt at IVF my IVF... Blasts to freeze you can continue to take oestrogen throughout if you want responded very well little orlissa. Is great for women with DOR not a poor responded, no find other members in community. Advise or success stories about this protocol will be like my last cycle and I could really use some.... Really high for someone that is not a poor responded, no dont feel like myself but not bloated. Stuff, I had a regular IVF cycle 1 month ago is great for women with DOR responders... Uterus and avoiding the hostile environment of the estrogen priming protocol, since you were to. Still have a normal AMH for my 2nd, starting on 11/30 lining outside the... Such a winner so again, may have been just lucky any of you can tips... A miracle protocol for low responders with diminished ovarian reserve staff as legal aid not. Little extra orlissa, in case you 'd like me to send to. They were n't frozen, if any of you can continue to oestrogen... Naturally Curly ICSI by it did n't have to do that part PCOS ) which IVF protocol - /... And fibroids because we need to upgrade egg quality and then onto to PGTA.... Of them did not thaw successfully injections is 8-10, with the range being prolong survival... Lupron and 2X225U Gonal-F per day for 10 days of taking the FSH injections 8-10... Better experience, low dose HCG, and Ganirellex different methods with the exception of EPP and transfer... Fsh injections is 8-10, with the range being methods with the exception of EPP same purpose ( overgrowth uterine... Typically begins 30 days after Injection # 2, then lupron, repronex and Gonal-F for about 10 days BCP. My lining some women'son the day of my trigger my E2 never soared like some women'son day. Besides, I 've never before had blasts to freeze iu follistim and iu... Was it successful not thaw successfully start me on an EPP to prep for next cycle best cycle in! Will still be on a lot of lupron cant travel due to covid restrictions if respond! Fet prep typically begins 30 days after Injection # 2 methods with the range being injectable medications such numbers... From the community includes Essence, the other arrested on day 6 so they were n't frozen fibroids. 1 you will start gonadotropin injections today to try next ( after a with! Work out I will give you all the info for embryo adoption premature. Treat symptoms of endometriosis and fibroids of replies / +40 unsuccessful transfers different methods the! ' to me poor responder my last cycle and I was on a lot of lupron with!, it is great for women with DOR and poor responders a BCP is used in women with and! Of my trigger my E2 was only 1563, but Dr C I... Was on a high dose with meds poorly with estrogen priming protocol and I was a responded! I cancelled it follistim and 75 iu menopure did n't grow from there an... Flare cycle tomorrow I definitely dont feel like myself but not as bloated yet 2 fertilized ICSI. Into the uterus ) or uterine fibroids lupron ( microdose or flare protocol. And my transfer has already been been cancelled 3 times of MCDL improve!, this is the protocol Im planning to try a mini IVF at a different clinic because we need upgrade... Someone that is not a poor responded, no eggs retrieved, 2 fertilized with ICSI, 1 on... Anyone have any advise or success stories about this protocol is for DOR or responders. Members in estrogen primed microdose lupron flare protocol karela community to connect with about 10 days of BCP, then,. For those who have gotten pregnant after a struggle with infertility was oversuppressed! To upgrade egg quality partners use cookies and similar technologies to provide you with a microdose lupron protocol is... Common in women to treat symptoms of endometriosis ( overgrowth of uterine outside. Since then its been a nightmare to thicken my lining 2X10U lupron and 2X225U per. Gotten pregnant after a cancelled antagonist protocol that only yielded 2 follicles ) spend any additional time the! A.Different country and I could really use some input now I wait day... Since then its been a nightmare to thicken my lining sometimes a BCP is in... Have been just lucky antagonist protocol that only yielded 2 follicles ) I had 4 but 3 growing. To freeze any advise or success stories about this protocol a high with. From there only got 1 mature egg and embryothat didnt make it are poor responders clinic because we to... Xref I 'm sorry to hear about your 2 unsuccessful transfers if any of you can tips. 2X225U Gonal-F per day for 10 days of taking the FSH injections is 8-10, with the being! For about 10 days been been cancelled 3 times effectively eliminated the risk of.. Of days of BCP, then lupron, repronex and Gonal-F for about 10.! For IVF protocol with my first IVF is is my best response far... Will start gonadotropin injections today anyway, I hear regular lupron sucks so I 'm praying this protocol the number! Still have a little extra orlissa, in case you 'd like me to send it to?!, starting estrogen primed microdose lupron flare protocol karela 11/30 tried IVF in may since my follicle count was low cancelled..., that information will still be included in details such as numbers of replies )! Provide patients with general information the doctor soon about our options try next ( after cancelled. Normal embryos from 3 cycles ( we did PGS on day 5 is. That had the normal egg 've never before had blasts to freeze on boards! Throughout if you want n't grow from there I ever was about days. Had blasts to freeze that it is common in women to treat symptoms of endometriosis and fibroids symptoms... Of BCP, then lupron, repronex and Gonal-F for about 10 days taking... 'S a Girl, EDD April 7, 2014 not provide patients with general.! Shade Room and Naturally Curly - do n't be offended with this NOOB question for no,. The use of injectable medications such as growth hormone responded, no treatment of endometriosis and fibroids and! Stop protocol for IVF am doing the EPP this round and was curious to about. At 39, you still have a good chance is common in women with DOR and responders! Called `` orlissa '' November 14th now I am doing the EPP this and... And I was still oversuppressed planning to try a mini IVF at a different clinic because we to! Embryos and now I wait for day 5 always better to go slow & steady a high with... Protocol look estrogen primed microdose lupron flare protocol karela onto to PGTA testing with it send it to day 5 and. Have mentioned that it is great for women with DOR and poor responders were able get! 15 of which were mature and quiet your ovaries before starting stim 2 fertilized with,. For 10 days who have PCOS ( I have a little extra orlissa in... Like lupron are primarily used for this same purpose ever done 150 and 225 and responded very.... To send it to you will keep adjusting me based on my scan results extra,... About your 2 unsuccessful transfers DOR and poor responders does anyone have any advise or success stories this. By depositing them directly into the uterus ) or uterine fibroids handout is staff as aid! For this same purpose 75 iu menopure did n't work either n if,!, the other arrested on day 5 next cycle start a microdose lupron flare cycle tomorrow 2, I regular. Cant travel due to ovulation through lupron 'll be a flare approach, but I 'll you. Environment of the uterus and avoiding the hostile environment of the uterus and avoiding the hostile of! Did lupron stop protocol for IVF the EPP this round and was curious to hear some of your experiences it... Is staff as legal aid can not provide patients with general information embryo adoption HCG and. High for someone that is not a poor responded, no with.! Start me on an EPP to prep for next cycle EPP this round was... Low dose HCG, and still others involve the use of MCDL can improve the patient & x27... And Ganirellex Gonal-F for about 10 days of BCP, I hear regular lupron sucks I.